pI: 7.1515 |
Length (AA): 1191 |
MW (Da): 137897 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
229 | 603 | 1z6a (A) | 11 | 788 | 25.00 | 0 | 1 | 0.62 | -0.47 |
803 | 942 | 1fuk (A) | 235 | 368 | 15.00 | 0 | 0.78 | 0.38 | -1.34 |
190 | 1023 | 5jxr (A) | 136 | 712 | 40.00 | 0 | 1 | 0.454052 | 1.79 |
244 | 536 | 5hzr (A) | 554 | 853 | 44.00 | 0 | 1 | 0.765812 | -0.47 |
807 | 957 | 1t5i (A) | 267 | 410 | 22.00 | 0 | 1 | 0.468384 | -1.02 |
1018 | 1190 | 4uos (A) | 2 | 179 | 10.00 | 0.1 | 0.02 | 0.308056 | -1.02 |
1021 | 1177 | 5cwj (A) | 3 | 160 | 13.00 | 0.81 | 0.04 | 0.286622 | -0.72 |
1029 | 1074 | 4wik (A) | 543 | 588 | 33.00 | 0.82 | 0.05 | 0.650423 | -2.84 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127568)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G12810 | photoperiod-independent early flowering 1 protein |
Babesia bovis | BBOV_IV011770 | snf2-related chromatin remodeling factor SRCAP |
Brugia malayi | Bm1_20790 | SNF2 family N-terminal domain containing protein |
Candida albicans | CaO19.1871 | putative RNA helicase |
Candida albicans | CaO19.9427 | putative RNA helicase |
Caenorhabditis elegans | CELE_Y111B2A.22 | Protein SSL-1, isoform C |
Cryptosporidium hominis | Chro.80359 | hypothetical protein |
Cryptosporidium parvum | cgd8_3080 | Swr1p like SWI/SNF2 family ATpase with a HSA domain at the N-terminus probably involved in chromatin remodelling |
Dictyostelium discoideum | DDB_G0267638 | CHR group protein |
Drosophila melanogaster | Dmel_CG9696 | domino |
Echinococcus granulosus | EgrG_000211600 | helicase |
Echinococcus multilocularis | EmuJ_000211600 | helicase |
Homo sapiens | ENSG00000183495 | E1A binding protein p400 |
Homo sapiens | ENSG00000080603 | Snf2-related CREBBP activator protein |
Leishmania braziliensis | LbrM.35.5440 | helicase, putative |
Leishmania donovani | LdBPK_365420.1 | SWI/SNF-related helicase, putative |
Leishmania infantum | LinJ.36.5420 | helicase, putative |
Leishmania major | LmjF.36.5190 | helicase, putative |
Leishmania mexicana | LmxM.36.5190 | helicase, putative |
Loa Loa (eye worm) | LOAG_00640 | SNF2 family domain-containing protein |
Mus musculus | ENSMUSG00000029505 | E1A binding protein p400 |
Mus musculus | ENSMUSG00000053877 | Snf2-related CREBBP activator protein |
Neospora caninum | NCLIV_019390 | SNF2 family N-terminal domain-containing protein, putative |
Onchocerca volvulus | OVOC7803 |
|
Plasmodium berghei | PBANKA_0710800 | Snf2-related CBP activator, putative |
Plasmodium falciparum | PF3D7_0820000 | Snf2-related CBP activator, putative |
Plasmodium knowlesi | PKNH_1313800 | Snf2-related CBP activator, putative |
Plasmodium vivax | PVX_089365 | helicase, putative |
Plasmodium yoelii | PY01180 | DOMINO B-related |
Saccharomyces cerevisiae | YDR334W | Swr1p |
Schistosoma japonicum | Sjp_0034870 | Helicase SRCAP, putative |
Schistosoma japonicum | Sjp_0100800 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma japonicum | Sjp_0034860 | expressed protein |
Schistosoma japonicum | Sjp_0130440 | Helicase ssl-1, putative |
Schistosoma mansoni | Smp_128890.2 | helicase |
Schistosoma mansoni | Smp_128890.1 | helicase |
Schmidtea mediterranea | mk4.001748.01 | Putative helicase |
Schmidtea mediterranea | mk4.000094.15 | Helicase domino |
Schmidtea mediterranea | mk4.000094.14 | |
Trypanosoma brucei gambiense | Tbg972.11.12020 | SNF2 DNA repair protein, putative,ATP-dependent helicase, putative,SNF2 family helicase, putative |
Trypanosoma brucei | Tb927.11.10730 | SWI/SNF-related helicase, putative |
Trypanosoma congolense | TcIL3000.11.11390 | SWI/SNF-related helicase, putative |
Trypanosoma cruzi | TcCLB.506155.70 | SWI/SNF-related helicase, putative |
Toxoplasma gondii | TGME49_280800 | SWI2/SNF2 SRCAP/Ino80 |
Theileria parva | TP01_1132 | ATP-dependent helicase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.2500 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2500 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2500 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.2500 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y111B2A.22 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y111B2A.22 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y111B2A.22 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0710800 | Plasmodium berghei | Essential | plasmo |
TGME49_280800 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.